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386(3):197-204
selective and orally bioavailable GPR39 agonist with an EC50 ~0
227(1):e13291
InChiKey: QYQFLAQHGHBIFA-UHFFFAOYSA-N
AG-494 - CAS# 133550-35-3 lin hydrochloride 386(3):197-204AG 494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0. 7 M). AG 494 inhibits the autophosphorylation of EGFR, ErbB2, HER1 2 and PDGF R with IC50s 1. 1, 39, 45 and 6 M, respectively. AG 494 blocks Cdk2 activation and inhibits EGF dependent DNA synthesis. Product information CAS Number: 133550 35 3 Molecular Weight: 280. 28 Formula: C16H12N2O3 Synonym: Tyrphostin AG 494 Chemical Name: (2E) 2 cyano 3 (3, 4